2Doç. Dr., Antalya Eğitim ve Araştırma Hastanesi , Fizik Tedavi ve Rehabilitasyon Bölümü, Romatoloji Kliniği, Antalya - TÜRKİYE Purpose: In this study, we aimed at detecting retinal toxicity induced by hydroxychloroquine at an early stage by evaluating the macular zone through spectral-domain optical coherence tomography (SD-OCT).
Material and Methods: In our study, 132 eyes from 66 patients who were taking hydroxychloroquine were assigned to Group 1, while 120 eyes from 60 age-matched healthy individuals were assigned to Group 2 as the control group. All patients included in the study were subjected to a detailed ophthalmological examination including automated threshold perimetry of the central 10 degrees. Macular retinal thickness in all patients was measured by Cirrus HD-OCT model 5000 device using macular cube 512x128 protocol. Moreover, the association of the cumulative dose of hydroxychloroquine and the duration of use with SD-OCT measurement parameters and visual field parameters was evaluated.
Results: Parafoveal and perifoveal retinal thickness of patients who were taking hydroxychloroquine was found to be statistically lower than that of the control group (p<0.05). The visual fi eld tests revealed a statistically signifi cant difference was found in MD and sLV values between the groups (p<0.05). No signifi cant association was found between the cumulative dose and duration of use in patients taking hydroxychloroquine and measured parameters of SD-OCT and visual fi eld parameters (p>0.05).
Conclusion: We found out that parafoveal and perifoveal retinal thickness decreased in patients taking hydroxychloroquine due to the retinal toxicity induced by the drug. It is important to detect this toxicity accurately at an early stage through SD-OCT measurements before it leads to permanent visual loss.
Keywords : Hydroxycholoroquine, SD-OCT, Retinal toxicity