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Prof. Dr., Marmara Üniversitesi Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı, İstanbul Retinal vein occlusion (RVO) is one of the most common occurring retinal vascular abnormalities. The management of macular edema that is the most common cause of visual loss in patients with BRVO has changed considerably over time. The laser photocoagulation has been shown to decrease the risk of visual loss and improve visual acuity (VA), however, visual recovery with the laser is usually slow and incomplete. It has made important contributions in improving the development of recent intravitreal agents, especially in anti-vascular endothelial growth factors (VEGF). Randomized clinical trials have reported optimal results with anti- VEGF agents (ranibizumab, bevacizumab, and afl ibercept) compared to laser therapy. This review article summarizes evidence from randomized controlled trials evaluating treatment options. Keywords : Retinal vein Occlusion, Medical Treatment