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¹Beyoğlu Göz Eğitim ve Araştırma Hastanesi, Göz Hastalıkları Kliniği, İstanbul, Uzm. Dr.
²Van Erciş Devlet Hastanesi, Göz Hastalıkları Kliniği, Van, Uz. Dr.
³Gazipaşa Devlet Hastanesi, Göz Hastalıkları Kliniği, Antalya, Uzm. Dr.
⁴Beyoğlu Göz Eğitim ve Araştırma Hastanesi, Göz Hastalıkları Kliniği, İstanbul, Asist. Dr.
⁵Beyoğlu Göz Eğitim ve Araştırma Hastanesi, Göz Hastalıkları Kliniği, İstanbul, Doç. Dr.
⁶Beyoğlu Göz Eğitim ve Araştırma Hastanesi, Göz Hastalıkları Kliniği, İstanbul, Prof. Dr Purpose: To evaluate the effects of intravitreal triamcinolone acetonide (IVTA), bevacizumab (IVB), and the combination of IVTA/IVB on the intraocular pressure (IOP) change in a 6-month follow-up period.
Materials and Methods: Two hundred and seven eyes of 194 consecutive patients (113 male, mean age 61±10 years) that received an intravitreal injection between January 2007 and January 2008 for the treatment of macular edema were evaluated retrospectively. Group 1 consisted of 100 eyes of 94 patients treated with 4 mg IVTA injection, Group 2 consisted of 32 eyes of 27 patients treated with 1.25 mg IVB, and Group 3 consisted of 75 eyes of 73 patients treated with a combination of 2 mg TA and 1.25 mg bevacizumab. The primary outcome measures of the study were change in IOP and the number of eyes with elevated IOP requiring glaucoma treatment.
Results: The initial IOP was similar in all groups (p=0.413). However, in all follow-up examinations the difference between the groups was significant (p value for all visits <0.05). Treatment for elevated IOP was required in 21% eyes following IVTA injection and in 4% eyes following IVTA/IVB injection (p=0.001). None of the eyes that received IVB required glaucoma treatment. IOP rise was highest at one month following IVTA injection and at one week following IVTA/IVB injection.
Conclusion: A significant relation between the steroid dose and IOP elevation was found. Reduction of steroid dose resulted in less frequent IOP elevation. Keywords : Intraocular pressure, intravitreal bevacizumab, intravitreal injection, intravitreal triamcinolone acetonide