We report a case of retinal pigment epithelial (RPE) tear occurred after intravitreal bevacizumab injection for serous pigment epithelial detachment (PED) from neovascular age-related macular degeneration. An 80-year-old woman who underwent 1.25 mg intravitreal bevacizumab treatment for serous PED secondary to AMD developed RPE tear 4 weeks following the second injection. Serial fundus fluorescein and indocyanine green angiography in addition to optical coherence tomography (OCT) imaging were obtained at baseline and during follow-up. OCT revealed that dome shaped RPE was changed to irregular folds just before the tear of RPE. Baseline visual acuity 20/25 decreased to 20/200 after RPE tear. The condition of the eye was stabilized with three additional injections of intravitreal bevacizumab. Fundus fluorescein angiography and OCT demonstrated resolved choroidal neovascularization. Visual acuity improved to 20/50 at the last examination. The patient remained stable 9 months after the last injection.