Purpose: To evaluate the photoreceptor layer status after antivascular endothelial growth factor (VEGF) therapy in choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) using spectral–domain optical coherence tomography (SD-OCT).

Materials and Methods: Sixteen eyes of 16 patients with CNV secondary to AMD with foveal thickness less than 250 μ after treatment with anti-VEGF therapy and with no obvious leakage on SD-OCT, along with 10 healthy subjects as controls, were imaged with SD-OCT. The inner and outer segment (IS/OS) photoreceptor layers were graded, and correlated with various characteristics including visual acuity.

Result: The IS/OS layer was detected in 6 (37%) eyes of patients with AMD and all eyes of the healthy control subjects (p<0.001). Eyes in patients with AMD with preserved IS/ OS had a significantly better BCVA and mean change in BCVA compared with eyes with absent IS/OS (p<0.01).

Conclusions: SD-OCT is a useful tool to visualize IS/OS status. The IS/OS status after anti-VEGF therapy in AMD patients with CNV correlates with BCVA and mean change in BCVA.